Combination Direct Renin Inhibition with Angiotensin Type 1 Receptor Blockade improves Aldosterone but does not improve Kidney Injury in the Transgenic Ren2 rat

Enhanced renin-angiotensin-aldosterone system (RAAS) activation contributes to proteinuria and chronic kidney disease by increasing glomerular and tubulointerstitial oxidative stress, promotion of fibrosis. Renin activation is the rate limiting step in angiotensin (Ang II) and aldosterone generation...

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Detalhes bibliográficos
Main Authors: Whaley-Connell, Adam, Habibi, Javad, Nistala, Ravi, Hayden, Melvin R, Pulakat, Lakshmi, Sinak, Catherine, Locher, Bonnie, Ferrario, Carlos M, Sowers, James R
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348429/
https://ncbi.nlm.nih.gov/pubmed/22465166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.regpep.2012.03.002
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