Comparative effect of direct renin inhibition and AT(1)R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat

Renin-angiotensin system (RAS) activation contributes to kidney injury through oxidative stress. Renin is the rate-limiting step in angiotensin (ANG II) generation. Recent work suggests renin inhibition improves proteinuria comparable to ANG type 1 receptor (AT(1)R) blockade (ARB). Thereby, we inves...

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Hlavní autoři: Whaley-Connell, Adam, Nistala, Ravi, Habibi, Javad, Hayden, Melvin R., Schneider, Rebecca I., Johnson, Megan S., Tilmon, Roger, Rehmer, Nathan, Ferrario, Carlos M., Sowers, James R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838585/
https://ncbi.nlm.nih.gov/pubmed/20007350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00373.2009
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