Mineralocorticoid Receptor-Dependent Proximal Tubule Injury Is Mediated by a Redox-Sensitive mTOR/S6K1 Pathway

BACKGROUND/AIMS: The mammalian target of rapamycin (mTOR) is a serine kinase that regulates phosphorylation (p) of its target ribosomal S6 kinase (S6K1), whose activation can lead to glomerular and proximal tubular cell (PTC) injury and associated proteinuria. Increased mTOR/S6K1 signaling regulates...

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Detalhes bibliográficos
Main Authors: Whaley-Connell, Adam T., Habibi, Javad, Nistala, Ravi, DeMarco, Vincent G., Pulakat, Lakshmi, Hayden, Melvin R., Joginpally, Tejaswini, Ferrario, Carlos M., Parrish, Alan R., Sowers, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2012
Assuntos:
Original Report: Laboratory Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316484/
https://ncbi.nlm.nih.gov/pubmed/22205374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000335079
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