Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression

There is emerging evidence that aldosterone can promote diastolic dysfunction and cardiac fibrosis independent of blood pressure effects, perhaps through increased oxidative stress and inflammation. Accordingly, this investigation was designed to ascertain if mineralocorticoid receptor blockade impr...

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Detalhes bibliográficos
Main Authors: Habibi, Javad, DeMarco, Vincent G., Ma, Lixin, Pulakat, Lakshmi, Rainey, William E., Whaley-Connell, Adam T., Sowers, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075026/
https://ncbi.nlm.nih.gov/pubmed/21239636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01000.2010
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