Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice

Overnutrition/obesity predisposes individuals, particularly women, to diastolic dysfunction (DD), an independent predictor of future cardiovascular disease. We examined whether low-dose spironolactone (Sp) prevents DD associated with consumption of a Western Diet (WD) high in fat, fructose, and sucr...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Bostick, Brian, Habibi, Javad, DeMarco, Vincent G., Jia, Guanghong, Domeier, Timothy L., Lambert, Michelle D., Aroor, Annayya R., Nistala, Ravi, Bender, Shawn B., Garro, Mona, Hayden, Melvin R., Ma, Lixin, Manrique, Camila, Sowers, James R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
Témata:
Integrative Cardiovascular Physiology and Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551127/
https://ncbi.nlm.nih.gov/pubmed/25747754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00898.2014
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