Low Dose Mineralocorticoid Receptor Blockade Prevents Western Diet-induced Arterial Stiffening in Female Mice

Women are especially predisposed to development of arterial stiffening secondary to obesity due to consumption of excessive calories. Enhanced activation of vascular mineralocorticoid receptors impairs insulin signaling, induces oxidative stress, inflammation and maladaptive immune responses. We tes...

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Veröffentlicht in:Hypertension
Hauptverfasser: DeMarco, Vincent G., Habibi, Javad, Jia, Guanghong, Aroor, Annayya R., Ramirez, Francisco, Martinez-Lemus, Luis A., Bender, Shawn B., Garro, Mona, Hayden, Melvin R., Sun, Zhe, Meininger, Gerald A., Manrique, Camila, Whaley-Connell, Adam, Sowers, James R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465849/
https://ncbi.nlm.nih.gov/pubmed/26015449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05674
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