Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression

There is emerging evidence that aldosterone can promote diastolic dysfunction and cardiac fibrosis independent of blood pressure effects, perhaps through increased oxidative stress and inflammation. Accordingly, this investigation was designed to ascertain if mineralocorticoid receptor blockade impr...

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Détails bibliographiques
Auteurs principaux: Habibi, Javad, DeMarco, Vincent G., Ma, Lixin, Pulakat, Lakshmi, Rainey, William E., Whaley-Connell, Adam T., Sowers, James R.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2011
Sujets:
Integrative Cardiovascular Physiology and Pathophysiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075026/
https://ncbi.nlm.nih.gov/pubmed/21239636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01000.2010
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