Mineralocorticoid Receptor-Dependent Proximal Tubule Injury Is Mediated by a Redox-Sensitive mTOR/S6K1 Pathway

BACKGROUND/AIMS: The mammalian target of rapamycin (mTOR) is a serine kinase that regulates phosphorylation (p) of its target ribosomal S6 kinase (S6K1), whose activation can lead to glomerular and proximal tubular cell (PTC) injury and associated proteinuria. Increased mTOR/S6K1 signaling regulates...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Whaley-Connell, Adam T., Habibi, Javad, Nistala, Ravi, DeMarco, Vincent G., Pulakat, Lakshmi, Hayden, Melvin R., Joginpally, Tejaswini, Ferrario, Carlos M., Parrish, Alan R., Sowers, James R.
Format: Artigo
Langue:Inglês
Publié: S. Karger AG 2012
Sujets:
Original Report: Laboratory Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316484/
https://ncbi.nlm.nih.gov/pubmed/22205374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000335079
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires