Angiotensin type 1 receptor resistance to blockade in the opossum proximal tubule cell due to variations in the binding pocket

Blockade of the angiotensin (ANG) II receptor type 1 (AT(1)R) with angiotensin receptor blockers (ARBs) is widely used in the treatment of hypertension. However, ARBs are variably effective in reducing blood pressure, likely due, in part, to polymorphisms in the ARB binding pocket of the AT(1)R. The...

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Main Authors: Nistala, Ravi, Andresen, Bradley T., Pulakat, Lakshmi, Meuth, Alex, Sinak, Catherine, Mandavia, Chirag, Thekkumkara, Thomas, Speth, Robert C., Whaley-Connell, Adam, Sowers, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625841/
https://ncbi.nlm.nih.gov/pubmed/23389452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00127.2012
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