Etravirine in CSF is highly protein bound

OBJECTIVES: Etravirine has high affinity for plasma drug-binding proteins, such as albumin and α(1)-acid glycoprotein, which limits the amount of unbound etravirine available to enter the CNS. The objective of this study was to compare total and unbound etravirine concentrations in CSF with plasma c...

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Main Authors: Nguyen, Anh, Rossi, Steven, Croteau, David, Best, Brookie M., Clifford, David, Collier, Ann C., Gelman, Benjamin, Marra, Christina, McArthur, Justin, McCutchan, J. Allen, Morgello, Susan, Simpson, David, Ellis, Ronald J., Grant, Igor, Capparelli, Edmund, Letendre, Scott, Abramson, Ian, Al-Lozi, Muhammad, Atkinson, J. Hampton, Fennema-Notestine, Christine, Gamst, Anthony C., Heaton, Robert K., Marcotte, Thomas D., Smith, Davey M., Taylor, Michael J., Theilmann, Rebecca, Vaida, Florin, Paul Woods, Steven, Cushman, Clint, Dawson, Matthew, Franklin, Donald, Jones, Trudy, Lewis, Kristen, Mintz, Letty, Teshome, Mengesha, Toperoff, Will
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2013
נושאים:
Original Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625433/
https://ncbi.nlm.nih.gov/pubmed/23335197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks517
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