Etravirine in CSF is highly protein bound

OBJECTIVES: Etravirine has high affinity for plasma drug-binding proteins, such as albumin and α(1)-acid glycoprotein, which limits the amount of unbound etravirine available to enter the CNS. The objective of this study was to compare total and unbound etravirine concentrations in CSF with plasma c...

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Detalhes bibliográficos
Main Authors: Nguyen, Anh, Rossi, Steven, Croteau, David, Best, Brookie M., Clifford, David, Collier, Ann C., Gelman, Benjamin, Marra, Christina, McArthur, Justin, McCutchan, J. Allen, Morgello, Susan, Simpson, David, Ellis, Ronald J., Grant, Igor, Capparelli, Edmund, Letendre, Scott, Abramson, Ian, Al-Lozi, Muhammad, Atkinson, J. Hampton, Fennema-Notestine, Christine, Gamst, Anthony C., Heaton, Robert K., Marcotte, Thomas D., Smith, Davey M., Taylor, Michael J., Theilmann, Rebecca, Vaida, Florin, Paul Woods, Steven, Cushman, Clint, Dawson, Matthew, Franklin, Donald, Jones, Trudy, Lewis, Kristen, Mintz, Letty, Teshome, Mengesha, Toperoff, Will
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625433/
https://ncbi.nlm.nih.gov/pubmed/23335197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks517
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