Etravirine in CSF is highly protein bound

OBJECTIVES: Etravirine has high affinity for plasma drug-binding proteins, such as albumin and α(1)-acid glycoprotein, which limits the amount of unbound etravirine available to enter the CNS. The objective of this study was to compare total and unbound etravirine concentrations in CSF with plasma c...

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Autori principali: Nguyen, Anh, Rossi, Steven, Croteau, David, Best, Brookie M., Clifford, David, Collier, Ann C., Gelman, Benjamin, Marra, Christina, McArthur, Justin, McCutchan, J. Allen, Morgello, Susan, Simpson, David, Ellis, Ronald J., Grant, Igor, Capparelli, Edmund, Letendre, Scott, Abramson, Ian, Al-Lozi, Muhammad, Atkinson, J. Hampton, Fennema-Notestine, Christine, Gamst, Anthony C., Heaton, Robert K., Marcotte, Thomas D., Smith, Davey M., Taylor, Michael J., Theilmann, Rebecca, Vaida, Florin, Paul Woods, Steven, Cushman, Clint, Dawson, Matthew, Franklin, Donald, Jones, Trudy, Lewis, Kristen, Mintz, Letty, Teshome, Mengesha, Toperoff, Will
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625433/
https://ncbi.nlm.nih.gov/pubmed/23335197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks517
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