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Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

PDE4 is one of eleven known cyclic nucleotide phosphodiesterase families and plays a pivotal role in mediating hydrolytic degradation of the important cyclic nucleotide second messenger, cyclic 3′5′ adenosine monophosphate (cAMP). PDE4 inhibitors are known to have anti-inflammatory properties, but t...

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Detalhes bibliográficos
Main Authors: Cameron, Ryan T., Coleman, Ryan G., Day, Jon P., Yalla, Krishna C., Houslay, Miles D., Adams, David R., Shoichet, Brian K., Baillie, George S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625111/
https://ncbi.nlm.nih.gov/pubmed/23473803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.02.026
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