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Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells
1. Monocytes and macrophages provide key targets for the action of novel anti-inflammatory therapeutics targeted at inhibition of PDE4 cAMP-specific phosphodiesterases. 2. PDE4 enzymes provide the dominant cAMP phosphodiesterase activity in U937 human monocytic cells. 3. Differentiation of U937 mono...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1574950/ https://ncbi.nlm.nih.gov/pubmed/15066910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705770 |
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