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Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.

We have isolated cDNAs encoding PDE4B4, a new cAMP-specific phosphodiesterase (PDE4) isoform with novel properties. The amino acid sequence of PDE4B4 demonstrates that it is encoded by the PDE4B gene, but that it differs from the previously isolated PDE4B1, PDE4B2 and PDE4B3 isoforms by the presence...

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Autori principali: Shepherd, Malcolm, McSorley, Theresa, Olsen, Aileen E, Johnston, Lee Ann, Thomson, Neil C, Baillie, George S, Houslay, Miles D, Bolger, Graeme B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223190/
https://ncbi.nlm.nih.gov/pubmed/12441002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021082
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