Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

PDE4 family cAMP phosphodiesterases play a pivotal role in determining compartmentalised cAMP signalling through targeted cAMP breakdown. Expressing the widely found PDE4D5 isoform, as both bait and prey in a yeast 2-hybrid system, we demonstrated interaction consistent with the notion that long PDE...

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Détails bibliographiques
Publié dans:Cell Signal
Auteurs principaux: Bolger, Graeme B., Dunlop, Allan J., Meng, Dong, Day, Jon P., Klussmann, Enno, Baillie, George S., Adams, David R., Houslay, Miles D.
Format: Artigo
Langue:Inglês
Publié: Elsevier Science Ltd 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371794/
https://ncbi.nlm.nih.gov/pubmed/25546709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2014.12.009
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