Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

The cAMP-specific phosphodiesterase PDE4D5 can interact with the signalling scaffold proteins RACK (receptors for activated C-kinase) 1 and β-arrestin. Two-hybrid and co-immunoprecipitation analyses showed that RACK1 and β-arrestin interact with PDE4D5 in a mutually exclusive manner. Overlay studies...

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Detalhes bibliográficos
Main Authors: Bolger, Graeme B., Baillie, George S., Li, Xiang, Lynch, Martin J., Herzyk, Pawel, Mohamed, Ahmed, High Mitchell, Lisa, McCahill, Angela, Hundsrucker, Christian, Klussmann, Enno, Adams, David R., Houslay, Miles D.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1525009/
https://ncbi.nlm.nih.gov/pubmed/16689683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060423
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