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Mdm2 Directs the Ubiquitination of β-Arrestin-sequestered cAMP Phosphodiesterase-4D5

β-Arrestin plays a key role in regulating β(2)-adrenoreceptor signaling by interdicting activation of adenylyl cyclase and selectively sequestering cAMP phosphodiesterase-4D5 (PDE4D5) for delivery of an active cAMP degrading system to the site of cAMP synthesis. Here we show that the β-agonist, isop...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Li, Xiang, Baillie, George S., Houslay, Miles D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713507/
https://ncbi.nlm.nih.gov/pubmed/19372219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008078
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