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β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from G(s) to G(i)
Phosphorylation of the β(2) adrenoreceptor (β(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide regulatory protein (G(i)). β-Arrestins recruit the cAMP-degrading PDE4 phospho...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC298705/ https://ncbi.nlm.nih.gov/pubmed/12552097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262787199 |
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