β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from G(s) to G(i)

Phosphorylation of the β(2) adrenoreceptor (β(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide regulatory protein (G(i)). β-Arrestins recruit the cAMP-degrading PDE4 phospho...

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Bibliographic Details
Main Authors: Baillie, George S., Sood, Arvind, McPhee, Ian, Gall, Irene, Perry, Stephen J., Lefkowitz, Robert J., Houslay, Miles D.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC298705/
https://ncbi.nlm.nih.gov/pubmed/12552097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262787199
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