Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

We have isolated cDNAs encoding PDE4A8 (phosphodiesterase 4 isoform A8), a new human cAMP-specific PDE4 isoform encoded by the PDE4A gene. PDE4A8 has a novel N-terminal region of 85 amino acids that differs from those of the related ‘long’ PDE4A4, PDE4A10 and PDE4A11 isoforms. The human PDE4A8 N-ter...

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Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Mackenzie, Kirsty F., Topping, Emma C., Bugaj-Gaweda, Bozena, Deng, Chengjun, Cheung, York-Fong, Olsen, Aileen E., Stockard, Cecil R., High Mitchell, Lisa, Baillie, George S., Grizzle, William E., De Vivo, Michael, Houslay, Miles D., Wang, Daguang, Bolger, Graeme B.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337886/
https://ncbi.nlm.nih.gov/pubmed/18095939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20071251
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