The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release

BACKGROUND AND PURPOSE: Increases in intracellular cyclic AMP (cAMP) augment the release/secretion of glucagon-like peptide-1 (GLP-1). As cAMP is hydrolysed by cAMP phosphodiesterases (PDEs), we determined the role of PDEs and particularly PDE4 in regulating GLP-1 release. EXPERIMENTAL APPROACH: GLP...

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Detalhes bibliográficos
Main Authors: Ong, WK, Gribble, FM, Reimann, F, Lynch, MJ, Houslay, MD, Baillie, GS, Furman, BL, Pyne, NJ
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707975/
https://ncbi.nlm.nih.gov/pubmed/19371330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00194.x
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