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Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells

1. Monocytes and macrophages provide key targets for the action of novel anti-inflammatory therapeutics targeted at inhibition of PDE4 cAMP-specific phosphodiesterases. 2. PDE4 enzymes provide the dominant cAMP phosphodiesterase activity in U937 human monocytic cells. 3. Differentiation of U937 mono...

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書目詳細資料
Main Authors: Shepherd, Malcolm C, Baillie, George S, Stirling, David I, Houslay, Miles D
格式: Artigo
語言:Inglês
出版: 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574950/
https://ncbi.nlm.nih.gov/pubmed/15066910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705770
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