Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality

Despite the recent first structural insight into the insulin-insulin receptor complex, the role of the C terminus of the B-chain of insulin in this assembly remains unresolved. Previous studies have suggested that this part of insulin must rearrange to reveal amino acids crucial for interaction with...

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Bibliografiske detaljer
Main Authors: Žáková, Lenka, Kletvíková, Emília, Veverka, Václav, Lepšík, Martin, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624407/
https://ncbi.nlm.nih.gov/pubmed/23447530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448050
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