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Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality

Despite the recent first structural insight into the insulin-insulin receptor complex, the role of the C terminus of the B-chain of insulin in this assembly remains unresolved. Previous studies have suggested that this part of insulin must rearrange to reveal amino acids crucial for interaction with...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Žáková, Lenka, Kletvíková, Emília, Veverka, Václav, Lepšík, Martin, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624407/
https://ncbi.nlm.nih.gov/pubmed/23447530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448050
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