Nalaganje...

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

The structural characterization of the insulin–insulin receptor (IR) interaction still lacks the conformation of the crucial B21–B30 insulin region, which must be different from that in its storage forms to ensure effective receptor binding. Here, it is shown that insulin analogues modified by natur...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Žáková, Lenka, Kletvíková, Emília, Lepšík, Martin, Collinsová, Michaela, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188015/
https://ncbi.nlm.nih.gov/pubmed/25286859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714017775
Oznake: Označite
Brez oznak, prvi označite!