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Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface
Apart from its role in insulin receptor (IR) activation, the C terminus of the B-chain of insulin is also responsible for the formation of insulin dimers. The dimerization of insulin plays an important role in the endogenous delivery of the hormone and in the administration of insulin to patients. H...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196076/ https://ncbi.nlm.nih.gov/pubmed/21880708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265249 |
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