Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface

Apart from its role in insulin receptor (IR) activation, the C terminus of the B-chain of insulin is also responsible for the formation of insulin dimers. The dimerization of insulin plays an important role in the endogenous delivery of the hormone and in the administration of insulin to patients. H...

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Bibliographic Details
Main Authors: Antolíková, Emília, Žáková, Lenka, Turkenburg, Johan P., Watson, Christopher J., Hančlová, Ivona, Šanda, Miloslav, Cooper, Alan, Kraus, Tomáš, Brzozowski, A. Marek, Jiráček, Jiří
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196076/
https://ncbi.nlm.nih.gov/pubmed/21880708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265249
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