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Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

Insulin is a key protein hormone that regulates blood glucose levels and, thus, has widespread impact on lipid and protein metabolism. Insulin action is manifested through binding of its monomeric form to the Insulin Receptor (IR). At present, however, our knowledge about the structural behavior of...

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Bibliografske podrobnosti
Main Authors: Jiráček, Jiří, Žáková, Lenka, Antolíková, Emília, Watson, Christopher J., Turkenburg, Johan P., Dodson, Guy G., Brzozowski, Andrzej M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836629/
https://ncbi.nlm.nih.gov/pubmed/20133841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911785107
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