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Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

Insulin is a key protein hormone that regulates blood glucose levels and, thus, has widespread impact on lipid and protein metabolism. Insulin action is manifested through binding of its monomeric form to the Insulin Receptor (IR). At present, however, our knowledge about the structural behavior of...

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Bibliografiske detaljer
Main Authors: Jiráček, Jiří, Žáková, Lenka, Antolíková, Emília, Watson, Christopher J., Turkenburg, Johan P., Dodson, Guy G., Brzozowski, Andrzej M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836629/
https://ncbi.nlm.nih.gov/pubmed/20133841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911785107
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