Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human Insulin

[Image: see text] The N-terminus of the B-chain of insulin may adopt two alternative conformations designated as the T- and R-states. Despite the recent structural insight into insulin–insulin receptor (IR) complexes, the physiological relevance of the T/R transition is still unclear. Hence, this st...

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Bibliographic Details
Main Authors: Kosinová, Lucie, Veverka, Václav, Novotná, Pavlína, Collinsová, Michaela, Urbanová, Marie, Moody, Nicholas R., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M., Žáková, Lenka
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047818/
https://ncbi.nlm.nih.gov/pubmed/24819248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500073z
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