Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules

Human insulin is a pivotal protein hormone controlling metabolism, growth, and aging and whose malfunctioning underlies diabetes, some cancers, and neurodegeneration. Despite its central position in human physiology, the in vivo oligomeric state and conformation of insulin in its storage granules in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Palivec, Vladimír, Viola, Cristina M., Kozak, Mateusz, Ganderton, Timothy R., Křížková, Květoslava, Turkenburg, Johan P., Halušková, Petra, Žáková, Lenka, Jiráček, Jiří, Jungwirth, Pavel, Brzozowski, Andrzej M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437240/
https://ncbi.nlm.nih.gov/pubmed/28348075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775924
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