Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules

Human insulin is a pivotal protein hormone controlling metabolism, growth, and aging and whose malfunctioning underlies diabetes, some cancers, and neurodegeneration. Despite its central position in human physiology, the in vivo oligomeric state and conformation of insulin in its storage granules in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Palivec, Vladimír, Viola, Cristina M., Kozak, Mateusz, Ganderton, Timothy R., Křížková, Květoslava, Turkenburg, Johan P., Halušková, Petra, Žáková, Lenka, Jiráček, Jiří, Jungwirth, Pavel, Brzozowski, Andrzej M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437240/
https://ncbi.nlm.nih.gov/pubmed/28348075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775924
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