Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules

Human insulin is a pivotal protein hormone controlling metabolism, growth, and aging and whose malfunctioning underlies diabetes, some cancers, and neurodegeneration. Despite its central position in human physiology, the in vivo oligomeric state and conformation of insulin in its storage granules in...

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Vydáno v:J Biol Chem
Hlavní autoři: Palivec, Vladimír, Viola, Cristina M., Kozak, Mateusz, Ganderton, Timothy R., Křížková, Květoslava, Turkenburg, Johan P., Halušková, Petra, Žáková, Lenka, Jiráček, Jiří, Jungwirth, Pavel, Brzozowski, Andrzej M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437240/
https://ncbi.nlm.nih.gov/pubmed/28348075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775924
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