Stim1, PKCδ and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development

Clonal deletion of autoreactive B cells is crucial to prevent autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterized a previously unrecognized Ca(2+)-driven Erk activation pathway, which was pro-apoptotic and biochemically distinct from DAG-i...

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Autores principales: Limnander, Andre, Depeille, Philippe, Freedman, Tanya S., Liou, Jen, Leitges, Michael, Kurosaki, Tomohiro, Roose, Jeroen P., Weiss, Arthur
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623929/
https://ncbi.nlm.nih.gov/pubmed/21441934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2016
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