Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development. RasGRP1 is important in some cancers and autoimmune diseases but, in contrast to SOS, its regulatory mechanisms are poorly understood. Activating signals lead to the membrane recruitment...

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Detalhes bibliográficos
Main Authors: Iwig, Jeffrey S, Vercoulen, Yvonne, Das, Rahul, Barros, Tiago, Limnander, Andre, Che, Yan, Pelton, Jeffrey G, Wemmer, David E, Roose, Jeroen P, Kuriyan, John
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728621/
https://ncbi.nlm.nih.gov/pubmed/23908768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00813
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