Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development. RasGRP1 is important in some cancers and autoimmune diseases but, in contrast to SOS, its regulatory mechanisms are poorly understood. Activating signals lead to the membrane recruitment...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Iwig, Jeffrey S, Vercoulen, Yvonne, Das, Rahul, Barros, Tiago, Limnander, Andre, Che, Yan, Pelton, Jeffrey G, Wemmer, David E, Roose, Jeroen P, Kuriyan, John
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2013
Teme:
Biophysics and Structural Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728621/
https://ncbi.nlm.nih.gov/pubmed/23908768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00813
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items