Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development. RasGRP1 is important in some cancers and autoimmune diseases but, in contrast to SOS, its regulatory mechanisms are poorly understood. Activating signals lead to the membrane recruitment...

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Main Authors: Iwig, Jeffrey S, Vercoulen, Yvonne, Das, Rahul, Barros, Tiago, Limnander, Andre, Che, Yan, Pelton, Jeffrey G, Wemmer, David E, Roose, Jeroen P, Kuriyan, John
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2013
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728621/
https://ncbi.nlm.nih.gov/pubmed/23908768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00813
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