A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs results in disease. An analysis of RasGRP1 SNP variants led to the conclusion that the charge of His 212 in RasGRP1 alters...

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Udgivet i:eLife
Main Authors: Vercoulen, Yvonne, Kondo, Yasushi, Iwig, Jeffrey S, Janssen, Axel B, White, Katharine A, Amini, Mojtaba, Barber, Diane L, Kuriyan, John, Roose, Jeroen P
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643099/
https://ncbi.nlm.nih.gov/pubmed/28952923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29002
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