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RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic β-Selection and ERK Activation Downstream of CXCR4

T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the thymus, the earliest thymic progenitors, called CD4(−)CD8(−) ‘double negative’ (DN) thymocytes, pass through a checkpoint termed “β-selection...

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Bibliografski detalji
Glavni autori: Golec, Dominic P., Dower, Nancy A., Stone, James C., Baldwin, Troy A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538756/
https://ncbi.nlm.nih.gov/pubmed/23308188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053300
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