RasGRP1 Is Essential for Ras Activation by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate in Epidermal Keratinocytes

RasGRP1 is a guanine nucleotide exchange factor for Ras that binds with high affinity to diacylglycerol analogs like the phorbol esters. Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetra...

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Bibliografiska uppgifter
Huvudupphovsmän: Sharma, Amrish, Luke, Courtney T., Dower, Nancy A., Stone, James C., Lorenzo, Patricia S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871438/
https://ncbi.nlm.nih.gov/pubmed/20308057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.100016
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