A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells

OBJECTIVE: Bryostatin-1 and related diacylglycerol (DAG) analogues activate RasGRPs in lymphocytes, thereby activating Ras and mimicking some aspects of immune receptor signaling. To define the role of RasGRPs in lymphocyte apoptosis and to identify potential therapeutic uses for DAG analogues in ly...

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Huvudupphovsmän: Stang, Stacey L., Lopez-Campistrous, Ana, Song, Xiaohua, Dower, Nancy A., Blumberg, Peter M., Wender, Paul A., Stone, James C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708980/
https://ncbi.nlm.nih.gov/pubmed/19100522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.09.008
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