RasGRPs Are Targets of the Anti-Cancer Agent Ingenol-3-Angelate

Ingenol-3–angelate (I3A) is a non-tumor promoting phorbol ester-like compound identified in the sap of Euphoria peplus. Similar to tumor promoting phorbol esters, I3A is a diacylglycerol (DAG) analogue that binds with high affinity to the C1 domains of PKCs, recruits PKCs to cellular membranes and p...

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Detalhes bibliográficos
Main Authors: Song, Xiaohua, Lopez-Campistrous, Ana, Sun, Lucy, Dower, Nancy A., Kedei, Noemi, Yang, Jing, Kelsey, Jessica S., Lewin, Nancy E., Esch, Tim E., Blumberg, Peter M., Stone, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749120/
https://ncbi.nlm.nih.gov/pubmed/23991094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072331
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