Synthesis, Biological, and Biophysical Studies of DAG-indololactones Designed as Selective Activators of RasGRP

The development of selective agents capable of discriminating between protein kinase C (PKC) isoforms and other diacylglycerol (DAG)-responsive C1 domain-containing proteins represents an important challenge. Recent studies have highlighted the role that Ras guanine nucleotide-releasing protein (Ras...

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Bibliografske podrobnosti
Main Authors: Garcia, Lia C., Donadío, Lucia Gandolfi, Mann, Ella, Kolusheva, Sofiya, Kedei, Noemi, Lewin, Nancy E., Hill, Colin S., Kelsey, Jessica S., Yang, Jing, Esch, Timothy E., Santos, Marina, Peach, Megan L., Kelley, James A., Blumberg, Peter M., Jelinek, Raz, Marquez, Victor E., Comin, Maria J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104769/
https://ncbi.nlm.nih.gov/pubmed/24794745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.04.024
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