RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma

Constitutive activation of Gαq signaling by mutations in GNAQ or GNA11 occurs in over 80% of uveal melanomas (UMs) and activates MAPK. Protein kinase C (PKC) has been implicated as a link, but the mechanistic details remained unclear. We identified PKC δ and ε as required and sufficient to activate...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Chen, Xu, Wu, Qiuxia, Depeille, Philippe, Chen, Peirong, Thornton, Sophie, Kalirai, Helen, Coupland, Sarah E., Roose, Jeroen P., Bastian, Boris C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499527/
https://ncbi.nlm.nih.gov/pubmed/28486107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.04.002
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