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RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
Constitutive activation of Gαq signaling by mutations in GNAQ or GNA11 occurs in over 80% of uveal melanomas (UMs) and activates MAPK. Protein kinase C (PKC) has been implicated as a link, but the mechanistic details remained unclear. We identified PKC δ and ε as required and sufficient to activate...
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| Veröffentlicht in: | Cancer Cell |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499527/ https://ncbi.nlm.nih.gov/pubmed/28486107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.04.002 |
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