Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations

Uveal melanoma (UM) is a genetically and biologically distinct type of melanoma, and once metastatic there is no effective treatment currently available. 80% of UMs harbor mutations in the Gα(q) family members GNAQ and GNA11. Understanding the effector pathways downstream of these oncoproteins is im...

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Bibliographic Details
Published in:Oncogene
Main Authors: Chen, Xu, Wu, Qiuxia, Tan, Lujian, Porter, Dale, Jager, Martine J., Emery, Caroline, Bastian, Boris C.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524511/
https://ncbi.nlm.nih.gov/pubmed/24141786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.418
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