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Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations
Uveal melanoma (UM) is a genetically and biologically distinct type of melanoma, and once metastatic there is no effective treatment currently available. 80% of UMs harbor mutations in the Gα(q) family members GNAQ and GNA11. Understanding the effector pathways downstream of these oncoproteins is im...
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| Veröffentlicht in: | Oncogene |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4524511/ https://ncbi.nlm.nih.gov/pubmed/24141786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.418 |
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