Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism

Uveal melanomas (UM) originate from melanocytes in the interior wall of the eye, namely from the iris, ciliary body and the choroid with marked differences in light exposure (from dark anterior to illuminated posterior). In contrast to UV radiation, focused or converging visible light readily reache...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: de Lange, Mark J., Razzaq, Lubna, Versluis, Mieke, Verlinde, Sven, Dogrusöz, Mehmet, Böhringer, Stefan, Marinkovic, Marina, Luyten, Gregorius P. M., de Keizer, Rob J. W., de Gruijl, Frank R., Jager, Martine J., van der Velden, Pieter A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569098/
https://ncbi.nlm.nih.gov/pubmed/26368812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138002
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