Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism

Uveal melanomas (UM) originate from melanocytes in the interior wall of the eye, namely from the iris, ciliary body and the choroid with marked differences in light exposure (from dark anterior to illuminated posterior). In contrast to UV radiation, focused or converging visible light readily reache...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: de Lange, Mark J., Razzaq, Lubna, Versluis, Mieke, Verlinde, Sven, Dogrusöz, Mehmet, Böhringer, Stefan, Marinkovic, Marina, Luyten, Gregorius P. M., de Keizer, Rob J. W., de Gruijl, Frank R., Jager, Martine J., van der Velden, Pieter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569098/
https://ncbi.nlm.nih.gov/pubmed/26368812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138002
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