Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism

Uveal melanomas (UM) originate from melanocytes in the interior wall of the eye, namely from the iris, ciliary body and the choroid with marked differences in light exposure (from dark anterior to illuminated posterior). In contrast to UV radiation, focused or converging visible light readily reache...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: de Lange, Mark J., Razzaq, Lubna, Versluis, Mieke, Verlinde, Sven, Dogrusöz, Mehmet, Böhringer, Stefan, Marinkovic, Marina, Luyten, Gregorius P. M., de Keizer, Rob J. W., de Gruijl, Frank R., Jager, Martine J., van der Velden, Pieter A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569098/
https://ncbi.nlm.nih.gov/pubmed/26368812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138002
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