GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma

Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11(Q209...

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Published in:Cell Rep
Main Authors: Moore, Amanda R., Ran, Leili, Guan, Youxin, Sher, Jessica J., Hitchman, Tyler D., Zhang, Jenny Q., Hwang, Catalina, Walzak, Edward G., Shoushtari, Alexander N., Monette, Sébastien, Murali, Rajmohan, Wiesner, Thomas, Griewank, Klaus G., Chi, Ping, Chen, Yu
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854482/
https://ncbi.nlm.nih.gov/pubmed/29490280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.081
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