Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockΔ19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockΔ19 mutation to a ∼900...

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Main Authors: Shimomura, Kazuhiro, Kumar, Vivek, Koike, Nobuya, Kim, Tae-Kyung, Chong, Jason, Buhr, Ethan D, Whiteley, Andrew R, Low, Sharon S, Omura, Chiaki, Fenner, Deborah, Owens, Joseph R, Richards, Marc, Yoo, Seung-Hee, Hong, Hee-Kyung, Vitaterna, Martha H, Bass, Joseph, Pletcher, Mathew T, Wiltshire, Tim, Hogenesch, John, Lowrey, Phillip L, Takahashi, Joseph S
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications, Ltd 2013
נושאים:
Genomics and Evolutionary Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622178/
https://ncbi.nlm.nih.gov/pubmed/23580255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00426
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