Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockΔ19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockΔ19 mutation to a ∼900...

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Detalhes bibliográficos
Main Authors: Shimomura, Kazuhiro, Kumar, Vivek, Koike, Nobuya, Kim, Tae-Kyung, Chong, Jason, Buhr, Ethan D, Whiteley, Andrew R, Low, Sharon S, Omura, Chiaki, Fenner, Deborah, Owens, Joseph R, Richards, Marc, Yoo, Seung-Hee, Hong, Hee-Kyung, Vitaterna, Martha H, Bass, Joseph, Pletcher, Mathew T, Wiltshire, Tim, Hogenesch, John, Lowrey, Phillip L, Takahashi, Joseph S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Genomics and Evolutionary Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622178/
https://ncbi.nlm.nih.gov/pubmed/23580255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00426
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