Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockΔ19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockΔ19 mutation to a ∼900...

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Autori principali: Shimomura, Kazuhiro, Kumar, Vivek, Koike, Nobuya, Kim, Tae-Kyung, Chong, Jason, Buhr, Ethan D, Whiteley, Andrew R, Low, Sharon S, Omura, Chiaki, Fenner, Deborah, Owens, Joseph R, Richards, Marc, Yoo, Seung-Hee, Hong, Hee-Kyung, Vitaterna, Martha H, Bass, Joseph, Pletcher, Mathew T, Wiltshire, Tim, Hogenesch, John, Lowrey, Phillip L, Takahashi, Joseph S
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2013
Soggetti:
Genomics and Evolutionary Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622178/
https://ncbi.nlm.nih.gov/pubmed/23580255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00426
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