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Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex
The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes about 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two bHLH-PAS domain protein subunits, CLOCK and BMAL1. Here we report t...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694778/ https://ncbi.nlm.nih.gov/pubmed/22653727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1222804 |
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