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Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes about 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two bHLH-PAS domain protein subunits, CLOCK and BMAL1. Here we report t...

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Autores principales: Huang, Nian, Chelliah, Yogarany, Shan, Yongli, Taylor, Clinton A., Yoo, Seung-Hee, Partch, Carrie, Green, Carla B., Zhang, Hong, Takahashi, Joseph S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694778/
https://ncbi.nlm.nih.gov/pubmed/22653727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1222804
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