CLOCK:BMAL1 is a pioneer-like transcription factor

The mammalian circadian clock relies on the master genes CLOCK and BMAL1 to drive rhythmic gene expression and regulate biological functions under circadian control. Here we show that rhythmic CLOCK:BMAL1 DNA binding promotes rhythmic chromatin opening. Mechanisms include CLOCK:BMAL1 binding to nucl...

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Bibliographic Details
Main Authors: Menet, Jerome S., Pescatore, Stefan, Rosbash, Michael
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2014
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894415/
https://ncbi.nlm.nih.gov/pubmed/24395244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.228536.113
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