Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

The mammalian circadian clock is based on a transcription–translation feedback loop (TTFL) in which CLOCK and BMAL1 proteins act as transcriptional activators of Cryptochrome and Period genes, which encode proteins that repress CLOCK–BMAL1 with a periodicity of ∼24 h. In this model, the mechanistic...

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Bibliographic Details
Main Authors: Ye, Rui, Selby, Cristopher P., Chiou, Yi-Ying, Ozkan-Dagliyan, Irem, Gaddameedhi, Shobhan, Sancar, Aziz
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4173159/
https://ncbi.nlm.nih.gov/pubmed/25228643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249417.114
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