Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

Mammalian circadian rhythms are generated by a transcription-based feedback loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2), which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24 hr periodicity. Here we pinpoint a key difference between CRY1...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Fribourgh, Jennifer L, Srivastava, Ashutosh, Sandate, Colby R, Michael, Alicia K, Hsu, Peter L, Rakers, Christin, Nguyen, Leslee T, Torgrimson, Megan R, Parico, Gian Carlo G, Tripathi, Sarvind, Zheng, Ning, Lander, Gabriel C, Hirota, Tsuyoshi, Tama, Florence, Partch, Carrie L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064333/
https://ncbi.nlm.nih.gov/pubmed/32101164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55275
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados