Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes

The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and night1–3. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis, and while rhythmic control of insulin r...

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Detalhes bibliográficos
Main Authors: Marcheva, Biliana, Moynihan Ramsey, Kathryn, Buhr, Ethan D., Kobayashi, Yumiko, Su, Hong, Ko, Caroline H., Ivanova, Ganka, Omura, Chiaki, Mo, Shelley, Vitaterna, Martha H., Lopez, James P., Philipson, Louis H., Bradfield, Christopher A., Crosby, Seth D., JeBailey, Lellean, Wang, Xiaozhong, Takahashi, Joseph S., Bass, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920067/
https://ncbi.nlm.nih.gov/pubmed/20562852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09253
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