Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes

The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and night1–3. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis, and while rhythmic control of insulin r...

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Main Authors: Marcheva, Biliana, Moynihan Ramsey, Kathryn, Buhr, Ethan D., Kobayashi, Yumiko, Su, Hong, Ko, Caroline H., Ivanova, Ganka, Omura, Chiaki, Mo, Shelley, Vitaterna, Martha H., Lopez, James P., Philipson, Louis H., Bradfield, Christopher A., Crosby, Seth D., JeBailey, Lellean, Wang, Xiaozhong, Takahashi, Joseph S., Bass, Joseph
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920067/
https://ncbi.nlm.nih.gov/pubmed/20562852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09253
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